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Crystal structure of the β2 adrenergic receptor–Gs protein complex
Adrenergic beta-2 Receptor Agonists, chemistry, metabolism, Animals, Catalytic Domain, Cattle, Crystallization, Crystallography, X-R
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polyme
Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved therapeutics are available. The CoV nsp14 exoribonucleas
Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options
Recent international epidemics of coronavirus-associated illnesses underscore the urgent medical and public health need for vaccine de
Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-
The continued emergence of Middle East Respiratory Syndrome (MERS) cases with a high case fatality rate stresses the need for the avai
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses in vitro and in vivo. Antiviral gets the jump on c
Simultaneous removal of nitrogen and phosphorous from domestic wastewater using Bacillus cereus
•Bacillus cereus GS-5 could concurrently remove NH4+-N, NO3−-N, NO2−-N and PO43−-P.•The main functional genes amplified in t
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
Adrenergic beta-2 Receptor Agonists, chemistry, metabolism, Animals, Biocatalysis, Catalytic Domain, Cattle, Crystallography, X-Ray,
Prostaglandin E₂ Promotes Colon Cancer Cell Growth through a Gs-Axin-β-Catenin Signaling Axis
How cyclooxygenase-2 (COX-2) and its proinflammatory metabolite prostaglandin E2 (PGE2) enhance colon cancer progression remains poorl
The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in t
GS-441524 inhibited replication of serotype II FIP virus (FIPV) in CRFK cell cultures at an EC50 of approximately 1 uM and no tox
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.
Calcitonin gene-related peptide (CGRP) is a widely expressed neuropeptide that has a major role in sensory neurotransmission. The CGRP
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